Mefenamic acid is a non-steroidal anti-inflammatory drug, typically used to ease period pain. Thanks to research study being carried out at The University of Manchester, nevertheless, it might eventually have another use– the treatment of Alzheimer’s illness. In laboratory trials, it has actually reversed amnesia and brain swelling in transgenic mice.
Led by Dr. David Brough, the Manchester team dealt with mice that were genetically become display Alzheimer’s- like symptoms. At the time of the experiments, the mice had started to establish memory problems.
All 20 animals had actually mini-pumps implanted under their skin, for a period of one month. Those pumps delivered determined doses of mefenamic acid to 10 of the mice, while the other ten got a placebo. At the end of the month, memory loss in mice receiving the acid had entirely vanished, while the placebo group stayed unchanged.
There is experimental evidence now to strongly suggest that inflammation in the brain makes Alzheimer’s disease worse,” states Brough. “Our research shows for the first time that mefenamic acid, a simple non-steroidal anti-inflammatory drug, can target an important inflammatory pathway called the NLRP3 inflammasome, which damages brain cells.”
That said, what deal with mice will not necessarily work on us, so human trials are now being prepared. Need to those likewise show appealing, it might not take long prior to extensive treatments consequently start.
“Because this drug is already available and the toxicity and pharmacokinetics of the drug is known, the time for it to reach patients should, in theory, be shorter than if we were developing completely new drugs,” says Brough.
Source: University of Manchester